Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13499256 | 0.87 | KDM4E (0.46) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499449 | 0.86 | KDM4E (0.45) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499359 | 0.85 | TSHR (0.47) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499249 | 0.83 | TSHR (0.45) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499349 | 0.72 | KDM4E (0.46) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499257 | 0.70 | KDM4E (0.46) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499454 | 0.70 | TSHR (0.43) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499374 | 0.70 | TSHR (0.45) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499251 | 0.69 | TSHR (0.51) | KDM4ETSHRUSP2ALOX15SMN1; SMN2 | |
| SCHEMBL13499419 | 0.68 | KDM4E (0.44) | KDM4ETSHRALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029620-A1 | SUBSTITUTED TRIAZOLINE, TETRAZOLONE AND IMIDAZOLONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029620-A1 | SUBSTITUTED TRIAZOLINE, TETRAZOLONE AND IMIDAZOLONE DERIVATIVES FOR USE AS A MEDICINE | ADRA2C, ADRB2, CHRNA5 | KDM4E 3793/4885TSHR 937/4885USP2 4507/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.