Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 12/20 | 0.54 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.54 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CYBB | P04839 | 2/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 2/20 | 0.47 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13501068 | 0.86 | PIM1 (0.54) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL13500712 | 0.85 | CYBB (0.57) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL103007 | 0.79 | PIM1 (0.61) | PIM1PIM2FLT3CYBBTGFBR2 | |
| SCHEMBL13501065 | 0.77 | PIM1 (0.59) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL13500714 | 0.75 | CYBB (0.51) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL22421502 | 0.75 | PIM1 (0.61) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL14302002 | 0.75 | CCR4 (0.53) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL3563380 | 0.74 | CYBB (0.59) | PIM1PIM2FLT3CYBBSLC2A1 | |
| SCHEMBL4340651 | 0.74 | RET (0.64) | PIM1PIM2FLT3SLC2A1RET | |
| SCHEMBL13500722 | 0.74 | CYBB (0.59) | PIM1PIM2FLT3CYBBSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7662826-B2 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD. (JP) | 2010-02-16 | — | — | US | disclosed |
| US-7662826-B2 | Pyrazolo [1,5-a] pyrimidine derivative and nad (p) h oxidase inhibitor containing the same | SHIONOGI & CO., LTD. (JP) | 2010-02-16 | — | — | US | disclosed |