Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 4/20 | 0.53 |
| ▸ | PIM1 | P11309 | 12/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14356890 | 0.86 | CCR4 (0.50) | CCR4PIM1PIM2TMEM97SIGMAR1 | |
| SCHEMBL4345111 | 0.85 | PIM1 (0.57) | PIM1PIM2FLT3 | |
| SCHEMBL14302001 | 0.78 | CCR4 (0.49) | CCR4TMEM97SIGMAR1 | |
| SCHEMBL103007 | 0.77 | PIM1 (0.61) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL13943374 | 0.76 | PIM1 (0.54) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL22421547 | 0.75 | PIM1 (0.55) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL13501067 | 0.75 | PIM1 (0.54) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL22421502 | 0.75 | PIM1 (0.61) | PIM1PIM2FLT3TGFBR2 | |
| SCHEMBL13943371 | 0.74 | NTRK1 (0.55) | PIM1PIM2FLT3 | |
| SCHEMBL13943911 | 0.74 | NTRK1 (0.55) | PIM1PIM2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |
| WO-2007147647-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME. | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2007-12-27 | — | — | WO | disclosed |