Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.76 |
| ▸ | PPARG | P37231 | 1/20 | 0.67 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.64 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.64 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.62 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22047184 | 0.91 | PPARG (0.78) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL11901042 | 0.91 | HDAC6 (0.70) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL8355389 | 0.91 | NR1H4 (0.64) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL27819662 | 0.89 | NR1H4 (0.71) | NR1H4PPARGCYP4Z1EPHX2RAB9A | |
| SCHEMBL27749373 | 0.89 | NR1H4 (0.71) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL16127853 | 0.87 | KMT2A (0.73) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL27819698 | 0.86 | NPC1 (0.63) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL27819670 | 0.86 | NR1H4 (0.63) | NR1H4PPARGHDAC6HDAC2HDAC8 | |
| SCHEMBL15600276 | 0.86 | NR1H4 (0.61) | NR1H4RAB9ANPC1MITFMAPK1 | |
| SCHEMBL457082 | 0.85 | HDAC6 (0.79) | NR1H4HDAC6HDAC2HDAC8ERCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100041645-A1 | RHO KINASE INHIBITORS | CIT, ROCK1, RHOT2 | NR1H4 2683/4885PPARG 3675/4885HDAC6 1508/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.