Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 5/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 5/20 | 0.35 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2661791 | 0.81 | GCK (0.42) | MAPTCACNA1HCACNA1GCACNA1IP2RY14 | |
| SCHEMBL2662463 | 0.81 | MEN1 (0.48) | MEN1KMT2ATP53NPC1GAA | |
| SCHEMBL3746609 | 0.78 | MAPT (0.34) | MAPTCACNA1HCACNA1GCACNA1IP2RY14 | |
| SCHEMBL13504193 | 0.77 | SCN3A (0.38) | MEN1KMT2AGRM4PDPK1ALDH1A1 | |
| SCHEMBL2660065 | 0.75 | P2RY14 (0.40) | MAPTCACNA1HCACNA1GCACNA1IP2RY14 | |
| SCHEMBL2660375 | 0.75 | MAPK10 (0.39) | MAPTCACNA1HTP53ALDH1A1 | |
| SCHEMBL2662291 | 0.73 | GCK (0.41) | MAPTTP53SCD | |
| SCHEMBL27797251 | 0.73 | LMNA (0.36) | MAPTTP53GRM4SCD | |
| SCHEMBL27797247 | 0.73 | LMNA (0.35) | MAPTTP53GRM4SCD | |
| SCHEMBL2661902 | 0.72 | MEN1 (0.45) | MAPTMEN1KMT2ATP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8299115-B2 | Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application | ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) | 2012-10-30 | — | — | US | disclosed |