Sugi Predict

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SCHEMBL3746609

SCHEMBL3746609

CCOC(=O)Cc1nc(NC(=O)c2cc(C(=O)C(C)C)cn2Cc2ccc(F)c(F)c2)sc1Cl

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 3/20 0.34
▸ CYP1A2 P05177 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ CYP2C9 P11712 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ GCK P35557 1/20 0.34
▸ NPC1 O15118 2/20 0.34
▸ RAB9A P51151 2/20 0.34
▸ GRM4 Q14833 2/20 0.34
▸ PKM P14618 1/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ KMT2A Q03164 2/20 0.34
▸ P2RX3 P56373 1/20 0.34
▸ KDM4E B2RXH2 1/20 0.33
▸ CACNA1H O95180 3/20 0.33
▸ CACNA1G O43497 2/20 0.33
▸ CACNA1I Q9P0X4 2/20 0.33
▸ P2RY14 Q15391 1/20 0.33
▸ GAA P10253 1/20 0.33
▸ P2RX7 Q99572 3/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2661261 0.92 MAPT (0.36) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2661791 0.90 GCK (0.42) MAPTGCKNPC1RAB9AGRM4
SCHEMBL2662504 0.89 GCK (0.35) MAPTGCKNPC1RAB9AGRM4
SCHEMBL2661726 0.87 CACNA1H (0.34) MAPTGCKNPC1RAB9AGRM4
SCHEMBL2660695 0.85 ALDH1A1 (0.35) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL2660774 0.83 GCK (0.34) MAPTGCKNPC1RAB9APKM
SCHEMBL2660595 0.83 GRM4 (0.36) GCKNPC1RAB9AGRM4PKM
SCHEMBL3748494 0.82 PDE3B (0.37) MAPTGCKGRM4MEN1KMT2A
SCHEMBL2662291 0.82 GCK (0.41) MAPTGCKP2RX7
SCHEMBL3748481 0.81 P2RX7 (0.36) MAPTGCKNPC1RAB9APKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2155720-B1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2013-07-17 — — EP claimed
US-8299115-B2 Pyrrole-2-carboxamide derivatives as glucokinase activators, their process and pharmaceutical application ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2012-10-30 — — US claimed
US-20100292143-A1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2010-11-18 — — US claimed
EP-2155720-B1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS PRIVATE LTD (IN) 2013-07-17 — — EP disclosed
US-20100292143-A1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION ADVINUS THERAPEUTICS PRIVATE LIMITED (IN) 2010-11-18 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100292143-A1 PYRROLE-2-CARBOXAMIDE DERIVATIVES AS GLUCOKINASE ACTIVATORS, THEIR PROCESS AND PHARMACEUTICAL APPLICATION GCK, PCK1, GCKR MAPT 2927/4885CYP1A2 699/4885CYP3A4 418/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.