Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | FABP4 | P15090 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 11/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.39 |
| ▸ | HTR1B | P28222 | 1/20 | 0.39 |
| ▸ | HTR1F | P30939 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4018278 | 0.91 | FABP4 (0.44) | HTTFABP4CYP3A4POLBMAPT | |
| SCHEMBL3621300 | 0.80 | HTT (0.49) | HTTFABP4CYP3A4POLBMAPT | |
| SCHEMBL3620463 | 0.76 | HTT (0.46) | HTTFABP4CYP3A4POLBMAPT | |
| SCHEMBL3614793 | 0.75 | HTT (0.45) | HTTFABP4CYP3A4POLBMAPT | |
| SCHEMBL13504563 | 0.75 | HTR6 (0.47) | CYP3A4HTR6CYP2D6HTR1ADRD2 | |
| SCHEMBL3623213 | 0.75 | HTR6 (0.51) | HTTFABP4CYP3A4POLBMAPT | |
| Trifluoroacetic Acid SCHEMBL4020079 | 0.74 | HTR6 (0.55) | HTTFABP4CYP3A4HTR6CYP2D6 | |
| SCHEMBL3623667 | 0.73 | BCHE (0.46) | HTTFABP4CYP3A4POLBMAPT | |
| SCHEMBL3622721 | 0.72 | HTR6 (0.61) | CYP3A4HTR6CYP2D6HTR1AHTR7 | |
| Trifluoroacetic Acid SCHEMBL4020301 | 0.71 | FABP4 (0.56) | FABP4CYP3A4HTR6CYP2D6HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046741-B1 | INDOLES AS 5-HT6 MODULATORS | PROXIMAGEN LTD (GB) | 2012-10-31 | — | — | EP | claimed |