Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 15/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.41 |
| ▸ | SGK1 | O00141 | 2/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.35 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.35 |
| ▸ | PRKCG | P05129 | 1/20 | 0.35 |
| ▸ | PRKCB | P05771 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3348998 | 0.92 | CAMKK2 (0.43) | ROCK1CYP3A4SGK1CAMKK2CIT | |
| SCHEMBL3347662 | 0.85 | ROCK1 (0.37) | ROCK1CYP3A4SGK1CAMKK2JAK2 | |
| SCHEMBL8442733 | 0.84 | ROCK1 (0.43) | ROCK1CYP3A4CITJAK2MAPK1 | |
| SCHEMBL8442699 | 0.83 | HTR2C (0.48) | ROCK1CYP3A4JAK2FLT3GSK3B | |
| SCHEMBL13539023 | 0.82 | ROCK1 (0.39) | ROCK1CYP3A4SGK1CAMKK2PDPK1 | |
| SCHEMBL8471584 | 0.78 | ROCK1 (0.38) | ROCK1CYP3A4SGK1CITJAK2 | |
| SCHEMBL3348310 | 0.74 | IL2 (0.39) | ROCK1CYP3A4SGK1CITJAK2 | |
| SCHEMBL1799923 | 0.73 | DYRK1A (0.50) | ROCK1CYP3A4SGK1CAMKK2PDPK1 | |
| SCHEMBL8443938 | 0.73 | CYP3A4 (0.37) | ROCK1CYP3A4PDPK1 | |
| SCHEMBL1800624 | 0.72 | PDPK1 (0.48) | ROCK1CYP3A4PDPK1JAK2PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100035878-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS RELATING TO APOPTOSIS AND/OR INFLAMMATION | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035878-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS RELATING TO APOPTOSIS AND/OR INFLAMMATION | NFKBIA, CHUK, MAP3K1 | ROCK1 418/4885CYP3A4 4639/4885SGK1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.