Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 8/20 | 0.36 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | CIT | O14578 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 8/20 | 0.35 |
| ▸ | IKBKB | O14920 | 2/20 | 0.34 |
| ▸ | CHUK | O15111 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | INSR | P06213 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442733 | 0.89 | ROCK1 (0.43) | ROCK1CYP3A4MAP3K11FLT3CIT | |
| SCHEMBL3347662 | 0.81 | ROCK1 (0.37) | ROCK1CYP3A4MAP3K11JAK2JAK3 | |
| SCHEMBL8442699 | 0.79 | HTR2C (0.48) | ROCK1CYP3A4FLT3JAK2GSK3B | |
| SCHEMBL13505143 | 0.78 | ROCK1 (0.41) | ROCK1CYP3A4FLT3CITJAK2 | |
| SCHEMBL3348998 | 0.78 | CAMKK2 (0.43) | ROCK1CYP3A4FLT3CITJAK2 | |
| SCHEMBL3348310 | 0.77 | IL2 (0.39) | ROCK1CYP3A4MAP3K11FLT3CIT | |
| SCHEMBL8442292 | 0.75 | ROCK1 (0.43) | ROCK1CYP3A4MAP3K11FLT3CIT | |
| SCHEMBL1801553 | 0.73 | MAP3K11 (0.45) | ROCK1CYP3A4MAP3K11FLT3CIT | |
| SCHEMBL13539023 | 0.71 | ROCK1 (0.39) | ROCK1CYP3A4FLT3CITJAK2 | |
| SCHEMBL1800577 | 0.70 | MAP3K11 (0.55) | MAP3K11TNIKSGK1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |