Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | IP6K3 | Q96PC2 | 2/20 | 0.49 |
| ▸ | IP6K2 | Q9UHH9 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.45 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL928538 | 0.97 | PTGS1 (0.54) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| Hydrochloric Acid SCHEMBL19119250 | 0.95 | PTGS1 (0.53) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL14789796 | 0.90 | RAB9A (0.51) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL15280716 | 0.88 | RAB9A (0.52) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL22467553 | 0.87 | ALDH1A1 (0.46) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL14711420 | 0.85 | NPC1 (0.40) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL4332210 | 0.85 | CYP1A2 (0.47) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL1563 | 0.85 | PTPN1 (0.47) | PTGS1PTPN1ALDH1A1IP6K1MAPT | |
| SCHEMBL4336589 | 0.85 | MAPT (0.51) | ALDH1A1IP6K1MAPTIP6K3IP6K2 | |
| SCHEMBL4676416 | 0.85 | PTGS1 (0.53) | PTGS1PTPN1ALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130072490-A1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC. (US) | 2013-03-21 | — | — | US | disclosed |
| WO-2011041462-A2 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130072490-A1 | POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | LPAR1, LPAR2, LPAR4 | PTGS1 922/4885PTPN1 931/4885ALDH1A1 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.