Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.49 |
| ▸ | PRKACA | P17612 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.45 |
| ▸ | CHUK | O15111 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27533178 | 0.98 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL2767758 | 0.86 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL876253 | 0.84 | NR3C1 (0.47) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL843461 | 0.84 | NR3C1 (0.47) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL2767849 | 0.83 | POLB (0.57) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL15834340 | 0.83 | ROCK1 (0.54) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL18722495 | 0.82 | ROCK1 (0.53) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL398666 | 0.81 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2POLBNR3C1ROCK1 | |
| SCHEMBL3560306 | 0.80 | IKBKB (0.58) | ALDH1A1SMN1; SMN2POLBNR3C1KEAP1 | |
| SCHEMBL4149990 | 0.80 | HPGD (0.61) | ALDH1A1SMN1; SMN2KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105102456-B | Azaquinazoline inhibitors of atypical protein kinase C | 癌症研究技术有限公司 | 2017-11-14 | — | — | CN | disclosed |
| CN-105102456-A | Azaquinazoline inhibitors of atypical protein kinase C | IGNYTA INC | 2015-11-25 | — | — | CN | disclosed |
| EP-1487453-B1 | N- ¬(2S)-4-(3,4-DIFLUOROBENZYL)MORPHOLIN-2-YL METHYL -2- 3-¬(METHYLSULPHONYL)AMINO PHENYL ACETAMIDE AS CCR3 ANTAGONIST FOR THE TREATMENT OF INFLAMMATORY CONDITIONS | GLAXO GROUP LTD (GB) | 2010-01-13 | — | — | EP | disclosed |
| CN-1678594-A | Morpholin-acetamide derivatives for the treatment of inflammatory diseases | GLAXO GROUP LTD (GB) | 2005-10-05 | — | — | CN | disclosed |
| CN-1642553-A | N-{'(2S) -4- (3, 4-difluorobenzyl) morpholin-2yl!methyl} -2-{3-' (methylsulphonyl) amino! phenyl}acetamide as CCR3 antagonist for the treatment of inflammatory conditions | GLAXO GROUP LTD (GB) | 2005-07-20 | — | — | CN | disclosed |