Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
| ▸ | GALR3 | O60755 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4572426 | 1.00 | XDH (0.41) | XDHLMNAKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL13513393 | 0.84 | SMN1; SMN2 (0.42) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL700362 | 0.84 | SMN1; SMN2 (0.42) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL700361 | 0.84 | SMN1; SMN2 (0.42) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL13513399 | 0.84 | KMT2A (0.41) | KMT2ANPC1RAB9ANOD1TNF | |
| SCHEMBL700698 | 0.83 | SMN1; SMN2 (0.44) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL700699 | 0.83 | SMN1; SMN2 (0.44) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL701288 | 0.83 | SMN1; SMN2 (0.44) | XDHLMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL701631 | 0.82 | ALDH1A1 (0.46) | XDHKMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL751366 | 0.82 | ALDH1A1 (0.49) | LMNAKMT2ASMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307382-B1 | AMINOTETRAHYDROINDAZOLOACETIC ACIDS | HOFFMANN LA ROCHE (CH) | 2011-12-21 | — | — | EP | disclosed |
| WO-2010006939-A1 | AMINOTETRAHYDROINDAZOLOACETIC ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-01-21 | — | — | WO | disclosed |