Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 13/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | RPS27 | P42677 | 2/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
| ▸ | TTK | P33981 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.33 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.33 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.33 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.33 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | PASK | Q96RG2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13514208 | 0.84 | MAPK8 (0.43) | MAPK8CDK2RPS27CCNA2TTK | |
| SCHEMBL13514478 | 0.83 | EGFR (0.42) | MAPK8CDK2RPS27CCNA2TTK | |
| SCHEMBL11702984 | 0.81 | MAPK8 (0.43) | MAPK8CDK2RPS27CCNA2TTK | |
| SCHEMBL11447309 | 0.78 | MAPK8 (0.62) | MAPK8RPS27MAPK9KDM4EPRKD3 | |
| SCHEMBL13514490 | 0.77 | LMNA (0.35) | MAPK8CDK2RPS27CCNA2TTK | |
| SCHEMBL13514459 | 0.74 | MAPK8 (0.72) | MAPK8CDK2RPS27CCNA2TTK | |
| SCHEMBL8888556 | 0.72 | MAPK8 (0.49) | MAPK8MAPK9KDM4EMAPK10ALDH1A1 | |
| SCHEMBL11102054 | 0.71 | ALDH1A1 (0.56) | MAPK8RPS27KDM4ECHUKALDH1A1 | |
| SCHEMBL11701910 | 0.71 | ADORA1 (0.52) | MAPK8CDK2CCNA2MAPK9KDM4E | |
| SCHEMBL8889038 | 0.71 | MAPK8 (0.48) | MAPK8MAPK9KDM4EMAPK10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007756-A1 | PYRIDINE DERIVATIVE HAVING TTK INHIBITION ACTIVITY | 塩野義製薬株式会社 (JP) | 2010-01-21 | — | — | WO | disclosed |