Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RGS4 | P49798 | 19/20 | 0.89 |
| ▸ | RGS8 | P57771 | 18/20 | 0.89 |
| ▸ | RGS16 | O15492 | 1/20 | 0.75 |
| ▸ | RGS19 | P49795 | 1/20 | 0.75 |
| ▸ | PRKCA | P17252 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13517716 | 0.94 | RGS4 (1.00) | RGS4RGS8RGS16RGS19GSK3B | |
| SCHEMBL13516931 | 0.92 | RGS4 (1.00) | RGS4RGS8RGS16RGS19 | |
| SCHEMBL13516585 | 0.89 | RGS4 (1.00) | RGS4RGS8PRKCAGSK3B | |
| SCHEMBL13517646 | 0.87 | RGS4 (1.00) | RGS4RGS8RGS16RGS19 | |
| SCHEMBL13517312 | 0.87 | RGS4 (1.00) | RGS4RGS8RGS16RGS19 | |
| SCHEMBL13517682 | 0.87 | RGS4 (0.89) | RGS4RGS8RGS16RGS19PRKCA | |
| SCHEMBL26420677 | 0.86 | RGS4 (0.86) | RGS4RGS8RGS16RGS19 | |
| SCHEMBL13516928 | 0.86 | RGS4 (1.00) | RGS4RGS8RGS16RGS19 | |
| SCHEMBL23757445 | 0.85 | RGS4 (0.80) | RGS4RGS8RGS16RGS19PRKCA | |
| SCHEMBL13517668 | 0.85 | RGS4 (1.00) | RGS4RGS8RGS16RGS19PRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-8865750-B2 | Small molecule inhibitors of RGS proteins | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-10-21 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | THE UNIVERSITY OF BATH (GB) | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277273-A1 | SMALL MOLECULE INHIBITORS OF RGS PROTEINS | RGS4, RGS16, RGS12 | RGS4 1/4885RGS8 4/4885RGS16 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.