RGS16 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL13516928	1.00	1/20
SCHEMBL13516931	0.86	1/20
SCHEMBL13517312	0.78	1/20
SCHEMBL13517646	0.78	1/20
SCHEMBL13517789	0.78	1/20
SCHEMBL13517395	0.76	1/20
SCHEMBL26420677	0.76	1/20
SCHEMBL13516707	0.75	1/20
SCHEMBL13517668	0.75	1/20
SCHEMBL13517716	0.75	1/20
SCHEMBL13517047	0.74	1/20
SCHEMBL13517115	0.74	1/20
SCHEMBL13517242	0.74	1/20
SCHEMBL13517756	0.74	1/20
SCHEMBL13516952	0.73	1/20
SCHEMBL13516956	0.72	1/20
SCHEMBL13516932	0.71	1/20
SCHEMBL13517061	0.70	1/20
SCHEMBL13517154	0.68	1/20
SCHEMBL13517266	0.68	1/20

Clinical trials — most relevant to RGS16 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Investigating the Potential Role of Aerosolized Retinoic Acid, a Potent Vitamin A Metabolite for Treating COVID-19 Anosmia and Retinoic Acid Insufficiency .A Novel Approach for Regaining Sense of Smell.	PHASE4	UNKNOWN
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old	PHASE2	ACTIVE_NOT_RECRUITING
Pentoxifylline as an Adjunctive in Treatment of Negative Symptoms in Chronic Schizophrenia	PHASE1/PHASE2	COMPLETED
Role of TLR4 in Environmental Asthma	PHASE1	COMPLETED
Effect of Gene Variants on Dopamine Receptor Natriuretic Responses	PHASE1	UNKNOWN
GSNOR Phenotyping/GSNO Challenge in Severe Asthma	EARLY_PHASE1	COMPLETED
Adrenocorticotropic Hormone (ACTH) Stimulation and G Protein	nan	COMPLETED
Acute Asthma Responsiveness and B2 Adrenergic Receptors Polymorphisms	nan	COMPLETED
Prescribing Asthma Controller Medication According to Gene Status to Improve Quality of Life in Young People With Asthma	nan	COMPLETED
Assessment of CXCL5 Level in SLE Patients and Its Correlation with Disease Activity	nan	NOT_YET_RECRUITING
Transcriptomic Profile of Patients Treated With Different Modalities of Spinal Cord Stimulation	nan	UNKNOWN
Thrombin Regulated Platelet Activation	nan	COMPLETED
Intravenous Terbutaline in Severe Status Asthmaticus	nan	UNKNOWN
Defining the Brain Phenotype of Children With Williams Syndrome	nan	RECRUITING
Relationship Between Genes Important in Blood Pressure Regulation and Blood Pressure Therapy in Hypertension	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
The Application of 68Ga-Pentixafor Alongside 68Ga-FAPI-04 PET/MR for Assessing Primary Aldosteronism.	nan	NOT_YET_RECRUITING
Genetics and Psychopathology in the 22q11 Deletion Syndrome	nan	UNKNOWN
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Quality of Life, Fatigue and Cognitive, Affective and Emotional Dysfunction in Patients With Cushing's Syndrome	nan	ACTIVE_NOT_RECRUITING
Inherited Reproductive Disorders	nan	RECRUITING
The Relationship Between Body Composition and Growth Hormone, SIRT Signaling, Protein Turnover and Insulin Sensitivity	nan	COMPLETED
Brain Receptors in Sympathetic Nervous System Regulation	nan	COMPLETED
Genetic Risk Factors for Severe Asthma	nan	COMPLETED
Precision Obesity Medicine: Genetic Prediction of Response to GLP-1/GIP Agonists.	nan	RECRUITING
Personalized Breast Cancer Screening	nan	ACTIVE_NOT_RECRUITING
The Genetics of Environmental Asthma	nan	COMPLETED
A Study on Risk Mutations of Vulnerability Genes of Schizophrenia	nan	UNKNOWN
The Influence of Acute Moderate-intensity Continuous Exercise on Appetite Regulation	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a RGS16 binder may also engage these)

Protein	Name	Similarity
P56700	—	1.000	P56700 →
F1S668	—	0.997	F1S668 →
O46471	—	0.996	O46471 →
P97428	—	0.995	P97428 →
RGS8	Regulator of G-protein signaling 8	0.995	landscape →
Q7SZC6	—	0.993	Q7SZC6 →
Q95K68	—	0.992	Q95K68 →
Q0P5H5	—	0.992	Q0P5H5 →
Q0R4E4	—	0.990	Q0R4E4 →
Q3S853	—	0.990	Q3S853 →
Q5R747	—	0.990	Q5R747 →
Q4R525	—	0.989	Q4R525 →
P49804	—	0.989	P49804 →
Q6DGI0	—	0.987	Q6DGI0 →
Q8BXT1	—	0.987	Q8BXT1 →
P49799	—	0.987	P49799 →
RGS4	Regulator of G-protein signaling 4	0.987	landscape →
Q29RM9	—	0.986	Q29RM9 →
Q99PG4	—	0.986	Q99PG4 →
O08849	—	0.985	O08849 →
Q9JHX0	—	0.985	Q9JHX0 →
O15539	—	0.984	O15539 →
O08899	—	0.984	O08899 →
Q6RG78	—	0.984	Q6RG78 →
P41220	—	0.984	P41220 →
Q9QZB0	—	0.983	Q9QZB0 →
P97844	—	0.983	P97844 →
O08850	—	0.983	O08850 →
Q9NS28	—	0.983	Q9NS28 →
P49800	—	0.982	P49800 →