Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | ACVRL1 | P37023 | 15/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10101529 | 0.92 | PIK3CD (0.39) | DOT1LPIK3CDACVRL1 | |
| SCHEMBL13519777 | 0.90 | DOT1L (0.41) | DOT1LPIK3CDACVRL1ADORA2A | |
| SCHEMBL644945 | 0.90 | DOT1L (0.41) | DOT1LPIK3CDACVRL1ADORA2A | |
| SCHEMBL10101528 | 0.87 | PIK3CD (0.40) | DOT1LPIK3CDACVRL1PRMT5 | |
| SCHEMBL10101525 | 0.86 | PIK3CD (0.40) | DOT1LPIK3CDACVRL1 | |
| SCHEMBL13519824 | 0.83 | ADORA2A (0.37) | PIK3CDACVRL1ADORA2A | |
| SCHEMBL13519812 | 0.80 | ACVRL1 (0.37) | ACVRL1ADORA2A | |
| SCHEMBL13519792 | 0.80 | DOT1L (0.46) | DOT1LPIK3CDACVRL1ADORA2APRMT5 | |
| SCHEMBL10101592 | 0.80 | DOT1L (0.44) | DOT1LPIK3CDACVRL1ADORA2APRMT5 | |
| SCHEMBL10101526 | 0.79 | PIK3CD (0.40) | DOT1LPIK3CDACVRL1PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002877-A2 | BYCYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS | BIOTA SCIENTIFIC MANAGEMENT (AU) | 2010-01-07 | — | — | WO | disclosed |