SCHEMBL13519829

SCHEMBL13519829

C[C@@]1(O)C(O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O[C@H]1c1ccc2c(N)ncnn12

nearest known ligand 0.79

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
POLRMT O00411 1/20 0.55
P2RY2 P41231 3/20 0.49
P2RY4 P51582 1/20 0.49
P2RX1 P51575 3/20 0.45
P2RX3 P56373 3/20 0.45
P2RX4 Q99571 2/20 0.45
P2RX2 Q9UBL9 2/20 0.44
RNASEL Q05823 2/20 0.43
ENTPD1 P49961 1/20 0.42
P2RY1 P47900 3/20 0.41
SRC P12931 1/20 0.41
ALDH1A1 P00352 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16710862 1.00 POLRMT (0.55) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL3699139 1.00 POLRMT (0.55) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL3696204 0.98 POLRMT (0.52) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL15682895 0.92 POLRMT (0.55) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL3703700 0.91 POLRMT (0.45) POLRMTP2RY2P2RY4RNASELP2RY1
SCHEMBL16480932 0.90 POLRMT (0.54) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL10149537 0.90 POLRMT (0.56) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL24699883 0.88 POLRMT (0.52) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL17129839 0.88 POLRMT (0.52) POLRMTP2RY2P2RY4P2RX1P2RX3
SCHEMBL12254003 0.88 P2RY2 (0.45) POLRMTP2RY2P2RY4P2RX1P2RX3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010002877-A2 BYCYCLIC NUCLEOSIDES AND NUCLEOTIDES AS THERAPEUTIC AGENTS BIOTA SCIENTIFIC MANAGEMENT (AU) 2010-01-07 WO disclosed