Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.81 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 5/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metamizole SCHEMBL24997 | 0.90 | PTGS1 (1.00) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL867884 | 0.88 | PTGS1 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL27828487 | 0.88 | PTGS1 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL27598082 | 0.88 | PTGS1 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL867882 | 0.87 | PTGS1 (0.95) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL16823495 | 0.87 | PTGS1 (0.95) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13524335 | 0.85 | PTGS1 (0.78) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13652746 | 0.83 | PTGS1 (0.70) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13652744 | 0.80 | PTGS1 (0.63) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13524551 | 0.80 | PTGS1 (0.73) | PTGS1ALOX15KDM4EMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645747-B2 | Improved pharmacokinetic properties, oral bioavailability; side effect reduction | GILEAD SCIENCES, INC. (US) | 2010-01-12 | — | — | US | disclosed |
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | CANNIZZARO CARINA | 2009-10-01 | — | — | US | disclosed |
| US-7432261-B2 | Anti-inflammatory phosphonate compounds | GILEAD SCIENCES, INC. (US) | 2008-10-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247488-A1 | ANTI-INFLAMMATORY PHOSPHONATE COMPOUNDS | PHOSPHO1, TNF, PTGES | PTGS1 6/4885ALOX15 82/4885KDM4E 4225/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.