Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Metamizole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.97 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 1/20 | 0.73 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.73 |
| ▸ | THRB | P10828 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.58 |
| ▸ | BCHE | P06276 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metamizole SCHEMBL867882 | 0.99 | PTGS1 (0.95) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL16823495 | 0.99 | PTGS1 (0.95) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL24997 | 0.99 | PTGS1 (1.00) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL27598082 | 0.97 | PTGS1 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL27828487 | 0.97 | PTGS1 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13524328 | 0.88 | PTGS1 (0.81) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL27870014 | 0.87 | PTGS1 (0.75) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| SCHEMBL13524335 | 0.86 | PTGS1 (0.78) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL24996 | 0.85 | ALOX15 (1.00) | PTGS1ALOX15KDM4EMAPTALOX12 | |
| Metamizole SCHEMBL24995 | 0.84 | ALOX15 (0.97) | PTGS1ALOX15KDM4EMAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106456550-A | Multiparticles safeguarded against ethanolic dose-dumping | 格吕伦塔尔有限公司 | 2017-02-22 | — | — | CN | disclosed |
| EP-2440211-B1 | USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE | CRISTALIA PROD QUIMICOS FARM (BR) | 2013-10-09 | — | — | EP | disclosed |
| US-8541395-B2 | Use of telocinobufagin as an analgesic in the treatment of acute and chronic pains | CRISTALIA PRODUTOS QUIMICOS FARMACEUTICOS LTDA. (BR) | 2013-09-24 | — | — | US | disclosed |
| US-20130243860-A1 | STANDARDIZED PLANT EXTRACT, PROCESS FOR OBTAINING THE SAME AND USES THEREOF | FUNDACAO UNIVERSIDADE DO VALE DO ITAJAI (BR) | 2013-09-19 | — | — | US | disclosed |
| US-8404283-B2 | Standardized plant extract, process for obtaining the same and uses thereof | Eurofarma Laboratorios LTDA (BR) | 2013-03-26 | — | — | US | disclosed |
| EP-2440211-A1 | USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE | Cristália Produtos Químicos Farmacêuticos LTDA. (BR) | 2012-04-18 | — | — | EP | disclosed |
| US-20120077788-A1 | USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE | GENPHARMA CONSULTORIA FARMACEUTICA E GENETICA LTDA. (BR) | 2012-03-29 | — | — | US | disclosed |
| CN-102186480-A | Pharmaceutical combination comprising 6-dimethylaminomethyl-1- (3-methoxy-phenyl) -cyclohexane-1, 3-diol and a non-steroidal anti-inflammatory drug | GRUENENTHAL GMBH | 2011-09-14 | — | — | CN | disclosed |
| WO-2010135798-A1 | USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE | Cristália Produtos Químicos Farmacêuticos Ltda. (BR) | 2010-12-02 | — | — | WO | disclosed |
| US-20100303907-A1 | STANDARDIZED PLANT EXTRACT, PROCESS FOR OBTAINING THE SAME AND USES THEREOF | EUROFARMA LABORATÓRIOS LTDA. (BR) | 2010-12-02 | — | — | US | disclosed |
| EP-2217257-A2 | A STANDARDIZED PLANT EXTRACT, PROCESS FOR OBTAINING THE SAME AND USES THEREOF | Eurofarma Laboratórios Ltda. (BR) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009052600-A2 | A STANDARDIZED PLANT EXTRACT, PROCESS FOR OBTAINING THE SAME AND USES THEREOF | EUROFARMA LABORATÓRIOS LTDA. (BR) | 2009-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077788-A1 | USE OF TELOCINOBUFAGIN AS AN ANALGESIC IN THE TREATMENT OF ACUTE AND CHRONIC PAINS; PHARMACEUTICAL COMPOSITION CONTAINING TELOCINOBUFAGIN AND ITS USE | TSN, TTN, OPRL1 | PTGS1 1276/4885ALOX15 974/4885KDM4E 3160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.