Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.55 |
| ▸ | RAB9A | P51151 | 10/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.51 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18542962 | 0.84 | RAB9A (0.61) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL13525847 | 0.81 | S1PR1 (0.67) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14330929 | 0.78 | S1PR1 (0.72) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL5959967 | 0.74 | SMN1; SMN2 (0.85) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL14331473 | 0.73 | S1PR1 (0.67) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL13416827 | 0.71 | SMN1; SMN2 (0.79) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL19766696 | 0.70 | S1PR1 (0.78) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL13417238 | 0.70 | NPC1 (0.76) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL18542993 | 0.69 | NPC1 (0.65) | NPC1RAB9ATP53MAPTSMN1; SMN2 | |
| SCHEMBL19766695 | 0.69 | S1PR1 (0.70) | NPC1RAB9ATP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100010001-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100010001-A1 | NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS | S1PR1, S1PR3, S1PR4 | NPC1 1399/4885RAB9A 2501/4885TP53 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.