Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 1.00 |
| ▸ | ODC1 | P11926 | 2/20 | 0.80 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.80 |
| ▸ | BCHE | P06276 | 1/20 | 0.80 |
| ▸ | BACE1 | P56817 | 1/20 | 0.80 |
| ▸ | HIF1AN | Q9NWT6 | 12/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31376270 | 1.00 | ACHE (1.00) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL19960679 | 0.89 | PTPN1 (1.00) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL31376263 | 0.89 | PTPN1 (1.00) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL19960678 | 0.88 | PTPN1 (0.85) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL31376190 | 0.88 | ACHE (0.78) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL31376191 | 0.87 | PTPN1 (0.83) | ACHEODC1PTPN1BCHEBACE1 | |
| Lonchocarpin SCHEMBL29435870 | 0.86 | PTPN1 (0.83) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL16694388 | 0.86 | HIF1AN (0.87) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL31376176 | 0.86 | HIF1AN (0.87) | ACHEODC1PTPN1BCHEBACE1 | |
| SCHEMBL16694389 | 0.86 | HIF1AN (0.87) | ACHEODC1PTPN1BCHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112390774-B | Chalcone compound and preparation method thereof from ranunculus spinosus | 山东省分析测试中心 | 2022-05-17 | — | — | CN | claimed |
| CN-106905281-A | Suppress flavone compound of acetyl and butyrylcholine esterase and application thereof in thick fruit precipice beans rattan | 四川大学 | 2017-06-30 | — | — | CN | claimed |
| CN-112390774-B | Chalcone compound and preparation method thereof from ranunculus spinosus | 山东省分析测试中心 | 2022-05-17 | — | — | CN | disclosed |
| CN-114031592-A | Chalcone derivative, preparation thereof and application thereof in preparation of antitumor drugs or functional foods | 山东省分析测试中心 | 2022-02-11 | — | — | CN | disclosed |
| CN-112274505-B | Application of chalcone compound in preparation of medicine for treating Alzheimer disease and pharmaceutical composition | 山东省分析测试中心 | 2022-01-04 | — | — | CN | disclosed |
| CN-112402411-B | Application of chalcone compound in preparation of sleep improvement medicine | 山东省分析测试中心 | 2021-09-21 | — | — | CN | disclosed |
| CN-112402411-A | Application of chalcone compound in preparation of sleep improvement medicine | 山东省分析测试中心 | 2021-02-26 | — | — | CN | disclosed |
| CN-112390774-A | Chalcone compound and preparation method thereof from ranunculus spinosus | 山东省分析测试中心 | 2021-02-23 | — | — | CN | disclosed |
| CN-112274505-A | Application of chalcone compound in preparation of medicine for treating Alzheimer disease and pharmaceutical composition | 山东省分析测试中心 | 2021-01-29 | — | — | CN | disclosed |
| CN-106905281-B | Inhibit acetyl and the flavone compound of butyrylcholine esterase and application thereof in thick fruit precipice beans rattan | 四川大学 | 2019-10-08 | — | — | CN | disclosed |
| CN-106905281-A | Suppress flavone compound of acetyl and butyrylcholine esterase and application thereof in thick fruit precipice beans rattan | 四川大学 | 2017-06-30 | — | — | CN | disclosed |
| WO-2010006189-A2 | SMALL-MOLECULE INHIBITORS OF HIF AND ANGIOGENESIS | EMORY UNIVERSITY (US) | 2010-01-14 | — | — | WO | disclosed |