Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.60 |
| ▸ | JAK2 | O60674 | 7/20 | 0.56 |
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 3/20 | 0.51 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536675 | 0.91 | JAK1 (0.72) | JAK1JAK2NAMPTTYK2KMT2A | |
| SCHEMBL13536516 | 0.85 | JAK1 (0.62) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL13536674 | 0.85 | JAK2 (0.71) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL2235155 | 0.84 | JAK1 (0.84) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL13536708 | 0.84 | JAK2 (0.57) | JAK1JAK2TYK2JAK3HDAC6 | |
| SCHEMBL13536667 | 0.83 | JAK2 (0.64) | JAK1JAK2TYK2SMN1; SMN2JAK3 | |
| SCHEMBL7979476 | 0.81 | JAK2 (0.67) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL13536663 | 0.80 | TYK2 (0.73) | JAK1JAK2TYK2NPC1RAB9A | |
| SCHEMBL13536709 | 0.79 | JAK2 (0.52) | JAK1JAK2TYK2SMN1; SMN2JAK3 | |
| SCHEMBL13536528 | 0.79 | JAK2 (0.61) | JAK1JAK2TYK2NPC1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |