Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.72 |
| ▸ | JAK2 | O60674 | 7/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13536674 | 0.92 | JAK2 (0.71) | JAK1JAK2TYK2 | |
| SCHEMBL13536577 | 0.91 | JAK1 (0.60) | JAK1JAK2NAMPTSMN1; SMN2TYK2 | |
| SCHEMBL13536667 | 0.90 | JAK2 (0.64) | JAK1JAK2HTTSMN1; SMN2TYK2 | |
| SCHEMBL7979476 | 0.89 | JAK2 (0.67) | JAK1JAK2POLBTYK2LMNA | |
| SCHEMBL13536528 | 0.86 | JAK2 (0.61) | JAK1JAK2TYK2 | |
| SCHEMBL13536527 | 0.86 | JAK2 (0.62) | JAK1JAK2NAMPTTYK2 | |
| SCHEMBL13536507 | 0.84 | JAK2 (0.61) | JAK1JAK2NAMPTTYK2 | |
| SCHEMBL13536707 | 0.84 | LMNA (0.57) | JAK1JAK2NAMPTPOLBTYK2 | |
| SCHEMBL13536706 | 0.84 | JAK2 (0.64) | JAK1JAK2NAMPTTYK2MAPT | |
| SCHEMBL2236657 | 0.84 | JAK1 (1.00) | JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010010189-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE AND INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2010-01-28 | — | — | WO | disclosed |