Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | KYNU | Q16719 | 1/20 | 0.57 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.56 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | CTSB | P07858 | 2/20 | 0.56 |
| ▸ | CTSS | P25774 | 2/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | TACR1 | P25103 | 2/20 | 0.54 |
| ▸ | TYR | P14679 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14623159 | 1.00 | ALDH1A1 (0.61) | ALDH1A1ALOX15KYNUNLRP3CTSL | |
| SCHEMBL9825830 | 0.90 | TYR (0.58) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL5288135 | 0.90 | TYR (0.58) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL7151822 | 0.89 | ALDH1A1 (0.74) | ALDH1A1ALOX15KYNUCTSLCTSB | |
| SCHEMBL329686 | 0.89 | ALDH1A1 (0.74) | ALDH1A1ALOX15KYNUCTSLCTSB | |
| SCHEMBL13536740 | 0.89 | POLB (0.63) | ALDH1A1ALOX15KYNUCTSLCTSB | |
| Hydrochloric Acid SCHEMBL7928050 | 0.88 | ALDH1A1 (0.72) | ALDH1A1ALOX15KYNUCTSLCTSB | |
| SCHEMBL9001871 | 0.88 | TACR1 (0.52) | ALDH1A1ALOX15CTSLCTSBCTSS | |
| SCHEMBL16224709 | 0.88 | ALDH1A1 (0.59) | ALDH1A1ALOX15KYNUCTSLCTSB | |
| SCHEMBL5122829 | 0.88 | ALDH1A1 (0.59) | ALDH1A1ALOX15KYNUCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7649015-B2 | Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds | GILEAD SCIENCES, INC. (US) | 2010-01-19 | — | — | US | disclosed |
| US-7371853-B2 | Macrocyclic β-secretase inhibitors for the treatment of Alzheimer's disease | MERCK & CO., INC. (US) | 2008-05-13 | — | — | US | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | GILEAD SCIENCES, INC. | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010489-A1 | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds | PPA1, PNP, PPME1 | ALDH1A1 3337/4885ALOX15 3167/4885KYNU 3479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.