Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MMP14 | P50281 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | ESRRA | P11474 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2423844 | 0.95 | PIM1 (0.48) | PIM1PIM2PIM3SIGMAR1PTPN1 | |
| SCHEMBL2423842 | 0.95 | PIM1 (0.48) | PIM1PIM2PIM3SIGMAR1PTPN1 | |
| SCHEMBL13537962 | 0.85 | GPR119 (0.49) | PIM1PIM2PIM3PTPN1NR1H4 | |
| SCHEMBL2421672 | 0.84 | PIM1 (0.60) | PIM1PIM2PIM3SIGMAR1GFER | |
| SCHEMBL2421675 | 0.84 | PIM1 (0.60) | PIM1PIM2PIM3SIGMAR1GFER | |
| SCHEMBL2421668 | 0.84 | PIM1 (0.60) | PIM1PIM2PIM3SIGMAR1GFER | |
| SCHEMBL2426855 | 0.83 | PIM1 (0.61) | PIM1PIM2PIM3SIGMAR1DRD2 | |
| SCHEMBL2426851 | 0.83 | PIM1 (0.61) | PIM1PIM2PIM3SIGMAR1DRD2 | |
| SCHEMBL2426595 | 0.82 | PIM1 (0.61) | PIM1PIM2PIM3SIGMAR1ALDH1A1 | |
| SCHEMBL2426598 | 0.82 | PIM1 (0.61) | PIM1PIM2PIM3SIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |