Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 5/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | GLS2 | Q9UI32 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2424046 | 0.84 | PIM2 (0.43) | NR1H4HPGDHRH3TTRPIM1 | |
| SCHEMBL12281622 | 0.84 | PIM2 (0.43) | NR1H4HPGDHRH3TTRPIM1 | |
| SCHEMBL2424048 | 0.84 | PIM2 (0.43) | NR1H4HPGDHRH3TTRPIM1 | |
| SCHEMBL13537931 | 0.82 | PIM2 (0.43) | NR1H4HPGDHRH3PIM1PIM2 | |
| SCHEMBL13537912 | 0.82 | PIM2 (0.41) | NR1H4HPGDHRH3PIM1PIM2 | |
| SCHEMBL2424504 | 0.80 | PIM2 (0.45) | NR1H4HPGDTTRPIM1PIM2 | |
| SCHEMBL12282366 | 0.80 | PIM2 (0.45) | NR1H4HPGDTTRPIM1PIM2 | |
| SCHEMBL2424501 | 0.80 | PIM2 (0.45) | NR1H4HPGDTTRPIM1PIM2 | |
| SCHEMBL13537610 | 0.78 | PIM2 (0.50) | NR1H4MAPTMEN1NPC1PKM | |
| SCHEMBL13537612 | 0.77 | PIM2 (0.58) | NR1H4MAPTMEN1NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |