Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.55 |
| ▸ | CCND1 | P24385 | 13/20 | 0.55 |
| ▸ | CDK2 | P24941 | 7/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.55 |
| ▸ | CDK1 | P06493 | 2/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 4/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.48 |
| ▸ | CCND2 | P30279 | 5/20 | 0.47 |
| ▸ | CCND3 | P30281 | 5/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 5/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355913 | 0.88 | STAT6 (0.51) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1356692 | 0.88 | STAT6 (0.55) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1356792 | 0.87 | CDK4 (0.53) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1356618 | 0.83 | CDK4 (0.53) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1355864 | 0.77 | STAT6 (0.53) | CDK4CCND1CDK2CCNE1STAT6 | |
| SCHEMBL672966 | 0.76 | JAK3 (0.48) | CDK4CCND1CDK2CDK1CCNB1 | |
| SCHEMBL1353701 | 0.76 | EIF2AK4 (0.60) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL5900462 | 0.76 | CDK4 (0.76) | CDK4CCND1CDK2CCNE1FGFR1 | |
| Hydrochloric Acid SCHEMBL23441075 | 0.75 | CDK4 (0.54) | CDK4CCND1CDK2CCNE1CDK1 | |
| SCHEMBL1356819 | 0.75 | CDK4 (0.59) | CDK4CCND1CDK2CCNE1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND1 160/4885CDK2 10/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND1 160/4885CDK2 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.