Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12281977 | 0.94 | HPGD (0.47) | HPGDDCTPP1BCL2A1LMNAPIM1 | |
| SCHEMBL2423643 | 0.94 | HPGD (0.47) | HPGDDCTPP1BCL2A1LMNAPIM1 | |
| SCHEMBL2423642 | 0.94 | HPGD (0.47) | HPGDDCTPP1BCL2A1LMNAPIM1 | |
| SCHEMBL13537995 | 0.84 | PARP1 (0.49) | HPGDPIM1PIM3PIM2KDM4E | |
| SCHEMBL13537625 | 0.79 | PIM2 (0.48) | PIM1PIM3PIM2SMN1; SMN2IGF1R | |
| SCHEMBL13537785 | 0.79 | PIM2 (0.43) | HPGDPIM1PIM3PIM2IGF1R | |
| SCHEMBL13537931 | 0.79 | PIM2 (0.43) | HPGDPIM1PIM3PIM2IGF1R | |
| SCHEMBL1580477 | 0.79 | PIM1 (0.45) | PIM1PIM3PIM2SMN1; SMN2 | |
| SCHEMBL12282171 | 0.79 | PIM1 (0.45) | PIM1PIM3PIM2SMN1; SMN2 | |
| SCHEMBL1580475 | 0.79 | PIM1 (0.45) | PIM1PIM3PIM2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |