Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 5/20 | 0.49 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.48 |
| ▸ | PIM1 | P11309 | 3/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580741 | 0.93 | PARP1 (0.50) | PARP1PIM2PIM1PIM3MAOA | |
| SCHEMBL12281591 | 0.93 | PARP1 (0.50) | PARP1PIM2PIM1PIM3MAOA | |
| SCHEMBL1580739 | 0.93 | PARP1 (0.50) | PARP1PIM2PIM1PIM3MAOA | |
| SCHEMBL13538077 | 0.84 | HPGD (0.46) | PIM2PIM1PIM3KDM4EIGF1R | |
| SCHEMBL13537625 | 0.83 | PIM2 (0.48) | PIM2PIM1PIM3RAB9AIGF1R | |
| SCHEMBL13537785 | 0.83 | PIM2 (0.43) | PIM2PIM1PIM3IGF1RNR1H4 | |
| SCHEMBL13537931 | 0.82 | PIM2 (0.43) | PIM2PIM1PIM3MAOAMAOB | |
| SCHEMBL13537611 | 0.82 | PIM2 (0.47) | PIM2PIM1PIM3RAB9AIGF1R | |
| SCHEMBL13537912 | 0.80 | PIM2 (0.41) | PIM2PIM1PIM3MAOAMAOB | |
| SCHEMBL1580477 | 0.79 | PIM1 (0.45) | PARP1PIM2PIM1PIM3MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010001169-A2 | CHEMICAL COMPOUNDS 251 | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | WO | disclosed |