Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9906716 | 0.90 | POLB (0.39) | POLBHTTUSP2ALDH1A1NPSR1 | |
| SCHEMBL13540714 | 0.81 | KMT2A (0.51) | NPC1L3MBTL1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9906715 | 0.72 | POLB (0.51) | POLBHTTUSP2ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL11635578 | 0.71 | L3MBTL1 (0.69) | POLBHTTUSP2ALDH1A1NPSR1 | |
| SCHEMBL9906706 | 0.70 | CXCR4 (0.44) | NPC1MEN1KMT2ASMN1; SMN2HPGD | |
| SCHEMBL13540772 | 0.67 | ALDH1A1 (0.40) | POLBHTTUSP2ALDH1A1NPSR1 | |
| SCHEMBL9906689 | 0.67 | MEN1 (0.36) | NPC1MEN1KMT2ASLC2A1MAPT | |
| SCHEMBL11663843 | 0.67 | HTT (0.58) | POLBHTTUSP2ALDH1A1NPSR1 | |
| Hydrochloric Acid SCHEMBL11638310 | 0.66 | HTT (0.57) | POLBHTTUSP2ALDH1A1NPSR1 | |
| SCHEMBL15706401 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652039-B2 | Such as 1-(2-((3-(4-chlorophenoxy)benzyl)amino)-3-phenyl-propyl)piperidin-4-ol for treatment of tuberculosis; solid phase synthesis | SEQUELLA, INC. (US) | 2010-01-26 | — | — | US | disclosed |