Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 3/20 | 0.33 |
| ▸ | LDHA | P00338 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217550 | 0.86 | ADAM17 (0.44) | ADAM17CHRM4PDPK1RPS6KB1SCN5A | |
| SCHEMBL8214415 | 0.84 | ADAM17 (0.46) | ADAM17CHRM4GPR6LDHA | |
| SCHEMBL8221817 | 0.84 | ADAM17 (0.43) | ADAM17CHRM4PDPK1RPS6KB1GPR6 | |
| SCHEMBL8214329 | 0.83 | ADAM17 (0.44) | ADAM17CHRM4PDPK1RPS6KB1USP30 | |
| SCHEMBL8222661 | 0.83 | ADAM17 (0.53) | ADAM17CHRM4SCN5ASCN9AFFAR4 | |
| SCHEMBL8221438 | 0.83 | ADAM17 (0.53) | ADAM17CHRM4RPS6KB1SCN5ASCN9A | |
| SCHEMBL8221453 | 0.83 | ADAM17 (0.53) | ADAM17CHRM4RPS6KB1SCN5ASCN9A | |
| SCHEMBL8273348 | 0.83 | ADAM17 (0.53) | ADAM17CHRM4RPS6KB1SCN5ASCN9A | |
| SCHEMBL8222795 | 0.83 | ADAM17 (0.43) | ADAM17CHRM4GPR6USP30 | |
| SCHEMBL8274446 | 0.83 | ADAM17 (0.43) | ADAM17CHRM4GPR6USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652020-B2 | novel hydantoin derivatives to inhibit matrix metalloproteinases (MMPs), a disintegrin and metalloproteases (ADAMs) and/or tumor necrosis factor alpha converting enzyme (TACE) and in so doing prevent the release of tumor necrosis factor alpha (TNF- alpha ); autoimmune diseases; side effect reduction | SCHERING CORPORATION (US) | 2010-01-26 | — | — | US | disclosed |