Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 6/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.34 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.34 |
| ▸ | EIF4E | P06730 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222795 | 1.00 | ADAM17 (0.43) | ADAM17CHRM4HDAC1HDAC2DPP8 | |
| SCHEMBL8273783 | 0.89 | HDAC1 (0.43) | ADAM17HDAC1HDAC2DPP8DPP4 | |
| SCHEMBL8221817 | 0.84 | ADAM17 (0.43) | ADAM17CHRM4HDAC1HDAC2GPR6 | |
| SCHEMBL13542023 | 0.83 | ADAM17 (0.44) | ADAM17CHRM4GPR6USP30 | |
| SCHEMBL8222661 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4MTORRPTORMLST8 | |
| SCHEMBL8273348 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4DPP8DPP4DPP9 | |
| SCHEMBL8221438 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4DPP8DPP4DPP9 | |
| SCHEMBL8221453 | 0.82 | ADAM17 (0.53) | ADAM17CHRM4DPP8DPP4DPP9 | |
| SCHEMBL8214415 | 0.82 | ADAM17 (0.46) | ADAM17CHRM4DPP8DPP9GPR6 | |
| SCHEMBL8213698 | 0.81 | ADAM17 (0.53) | ADAM17CHRM4DPP8DPP4DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |