Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 13/20 | 0.92 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.54 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.54 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.54 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4686130 | 0.96 | CCR5 (1.00) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL13544010 | 0.92 | CCR5 (0.78) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL4682434 | 0.88 | CCR5 (0.85) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL4740667 | 0.85 | CCR5 (0.80) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL13544007 | 0.84 | CCR5 (1.00) | CCR5OPRM1OPRL1OPRD1OPRK1 | |
| SCHEMBL4682424 | 0.84 | CCR5 (0.74) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL4683260 | 0.83 | CCR5 (0.73) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL4683230 | 0.82 | CCR5 (0.75) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL13544011 | 0.82 | CCR5 (1.00) | CCR5OPRM1OPRL1SLC6A9SLC6A5 | |
| SCHEMBL4680985 | 0.82 | CCR5 (0.74) | CCR5OPRM1OPRL1SLC6A9SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |