Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA3 | P07451 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544677 | 0.88 | POLB (0.44) | ATMPOLBAPEX1MEN1KMT2A | |
| SCHEMBL3531796 | 0.88 | ATM (0.48) | ATMPOLBAPEX1MEN1KMT2A | |
| SCHEMBL13865490 | 0.87 | POLB (0.43) | ATMPOLBAPEX1MEN1KMT2A | |
| SCHEMBL3528359 | 0.86 | FABP4 (0.41) | ATMMEN1KMT2AALDH1A1HSD17B10 | |
| SCHEMBL13869115 | 0.86 | POLB (0.42) | ATMPOLBAPEX1MEN1KMT2A | |
| SCHEMBL13544474 | 0.85 | APP (0.50) | ATMPOLBAPEX1MEN1KMT2A | |
| SCHEMBL13544476 | 0.82 | KDM4E (0.52) | ATMPOLBMEN1KMT2ATSHR | |
| SCHEMBL13544492 | 0.81 | ATM (0.57) | ATMPOLBMEN1KMT2ATSHR | |
| SCHEMBL7564592 | 0.80 | CISD1 (0.49) | ATMMEN1KMT2ATSHRCISD1 | |
| SCHEMBL13544519 | 0.79 | CA12 (0.55) | ATMPOLBMEN1KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |