Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.38 |
| ▸ | FEN1 | P39748 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13542976 | 0.89 | POLB (0.47) | POLBAPEX1ALDH1A1ATMALOX5AP | |
| SCHEMBL13542971 | 0.87 | KMT2A (0.41) | POLBAPEX1ATMMEN1KMT2A | |
| SCHEMBL13544481 | 0.87 | ATM (0.48) | POLBAPEX1ALDH1A1ATMMEN1 | |
| SCHEMBL13544677 | 0.87 | POLB (0.44) | POLBAPEX1ALDH1A1ATMALOX5AP | |
| SCHEMBL13542977 | 0.87 | ALOX5AP (0.38) | ALDH1A1ALOX5APFEN1MEN1KMT2A | |
| SCHEMBL13542972 | 0.84 | GSTO1 (0.45) | POLBAPEX1ALDH1A1ATMMEN1 | |
| SCHEMBL13869115 | 0.84 | POLB (0.42) | POLBAPEX1ALDH1A1ATMALOX5AP | |
| SCHEMBL13542968 | 0.83 | ATM (0.45) | POLBAPEX1ALDH1A1ATMALOX5AP | |
| SCHEMBL13542970 | 0.81 | KMT2A (0.43) | POLBAPEX1ALDH1A1MEN1KMT2A | |
| SCHEMBL13542973 | 0.81 | CA1 (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7531661-B2 | Indane compounds as CCR5 antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 2009-05-12 | — | — | US | disclosed |