Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.56 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | PPARG | P37231 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | APLNR | P35414 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13544741 | 0.91 | PPARG (0.61) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL3527747 | 0.91 | TAS1R3 (0.56) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL3524782 | 0.91 | TAS1R3 (0.59) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL13544514 | 0.86 | PPARG (0.61) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL3530201 | 0.85 | TAS1R3 (0.57) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL23985899 | 0.83 | TAS1R3 (0.71) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL30305533 | 0.83 | TAS1R3 (0.71) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL13544740 | 0.81 | MAPT (0.61) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL24914439 | 0.80 | TAS1R3 (0.66) | TAS1R3TAS1R1ALDH1A1GAAHPGD | |
| SCHEMBL13544512 | 0.76 | MAPT (0.61) | TAS1R3TAS1R1ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |
| US-7645771-B2 | CCR5 antagonists as therapeutic agents | SMITHKLINE BEECHAM CORP. (US) | 2010-01-12 | — | — | US | disclosed |