Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 1/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.37 |
| ▸ | HPGD | P15428 | 8/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3580550 | 0.85 | PDE5A (0.45) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL13545983 | 0.82 | PDE5A (0.44) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL13545988 | 0.81 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL3589518 | 0.78 | ADORA2A (0.39) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3594245 | 0.77 | PDE5A (0.47) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL13545982 | 0.75 | PDE5A (0.46) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL13545986 | 0.73 | ALDH1A1 (0.47) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL13545981 | 0.70 | PDE5A (0.47) | PDE5APDE1APDE1BPDE1CHPGDS | |
| SCHEMBL3588911 | 0.69 | ADORA2A (0.53) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3599988 | 0.69 | ALDH1A1 (0.43) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
| US-20100009973-A1 | Integrase Inhibitors 3 | AVEXA LIMITED (AU) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009973-A1 | Integrase Inhibitors 3 | TYMP, IMPDH1, IMPDH2 | PDE5A 531/4885PDE1A 2156/4885PDE1B 2475/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.