Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 2/20 | 0.63 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 9/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.53 |
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.52 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.52 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3404793 | 0.88 | MAPK14 (0.54) | KCNQ3KCNQ2MAPK14RAB9ANPC1 | |
| SCHEMBL31524100 | 0.83 | MAPT (0.60) | MAPK14RAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL4827723 | 0.83 | MAPT (0.60) | MAPK14RAB9ANPC1KMT2ASMN1; SMN2 | |
| SCHEMBL259371 | 0.82 | KMT2A (0.66) | RAB9ANPC1KMT2ASMN1; SMN2POLB | |
| SCHEMBL4704265 | 0.81 | MAPK14 (0.70) | KCNQ3KCNQ2MAPK14 | |
| SCHEMBL12764158 | 0.80 | RAB9A (0.68) | RAB9ANPC1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5897217 | 0.80 | LMNA (0.55) | KCNQ3KCNQ2RAB9ANPC1KMT2A | |
| SCHEMBL2303285 | 0.80 | KCNQ3 (0.80) | KCNQ3KCNQ2RAB9ANPC1KMT2A | |
| SCHEMBL25984187 | 0.80 | MAPK14 (0.60) | KCNQ3KCNQ2MAPK14SMARCA2SMARCA4 | |
| SCHEMBL4704601 | 0.80 | MAPK14 (0.68) | KCNQ3KCNQ2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7642276-B2 | Fused heteroaryl derivatives for use as P38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-05 | — | — | US | disclosed |
| US-7642276-B2 | Fused heteroaryl derivatives for use as P38 kinase inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 2010-01-05 | — | — | US | disclosed |