Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13547533 | 0.85 | MDM2 (0.53) | MDM2TP53HSD17B2 | |
| SCHEMBL15744018 | 0.79 | HSD17B2 (0.42) | MDM2HSD17B2SIGMAR1 | |
| SCHEMBL20208296 | 0.78 | SIGMAR1 (0.51) | HSD17B2TSHRSIGMAR1 | |
| SCHEMBL13395242 | 0.75 | SIGMAR1 (0.31) | HSD17B2SIGMAR1 | |
| SCHEMBL13413595 | 0.75 | SIGMAR1 (0.43) | MDM2TP53HSD17B2SIGMAR1P2RX7 | |
| SCHEMBL13547561 | 0.69 | FADS1 (0.38) | MDM2TP53TTR | |
| SCHEMBL22222475 | 0.69 | FADS1 (0.38) | MDM2TP53TTR | |
| SCHEMBL20794167 | 0.69 | FADS1 (0.38) | MDM2TP53TTR | |
| SCHEMBL9946558 | 0.67 | MDM2 (0.36) | MDM2TP53TTR | |
| SCHEMBL13950179 | 0.67 | MDM2 (0.36) | MDM2TP53TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7652049-B2 | 1-benzyl-4-[4'-fluoro-5'-isopropyl-2'-methoxy-4-(trifluoromethyl)biphenyl-2-yl]imidazolidin-2-one; cholesteryl ester transfer protein inhibitor; raising HDL-cholesterol, reducing LDL-cholesterol; atherosclerosis; antiinflammatory agent; synergistic mixture with other active ingredients | MERCK & CO., INC. (US) | 2010-01-26 | — | — | US | disclosed |