Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.49 |
| ▸ | GAK | O14976 | 3/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.44 |
| ▸ | BUB1 | O43683 | 2/20 | 0.44 |
| ▸ | STK10 | O94804 | 2/20 | 0.44 |
| ▸ | MAP3K1 | Q13233 | 2/20 | 0.44 |
| ▸ | PIP4K2C | Q8TBX8 | 2/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.44 |
| ▸ | CARS1 | P49589 | 1/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.43 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.43 |
| ▸ | FBP1 | P09467 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13549156 | 0.94 | EGFR (0.49) | EGFRGAKERBB2ERBB4FBP1 | |
| SCHEMBL13514655 | 0.88 | ALDH1A1 (0.48) | EGFRERBB2ALDH1A1MAPTLMNA | |
| SCHEMBL13549168 | 0.87 | EGFR (0.52) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL13549188 | 0.84 | EGFR (0.53) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL13549187 | 0.83 | FBP1 (0.48) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL13549214 | 0.83 | EGFR (0.45) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL1766099 | 0.83 | FBP1 (0.49) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL13514771 | 0.82 | ALDH1A1 (0.48) | EGFRERBB2ALDH1A1MAPTLMNA | |
| SCHEMBL13514769 | 0.81 | EGFR (0.54) | EGFRGAKRIPK2BUB1STK10 | |
| SCHEMBL13549100 | 0.79 | FBP1 (0.46) | EGFRGAKRIPK2BUB1STK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130217661-A1 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-08-22 | — | — | US | disclosed |
| US-20130217661-A1 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-08-22 | — | — | US | disclosed |
| US-8426430-B2 | Quinazoline derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-04-23 | — | — | US | disclosed |
| US-20100009958-A1 | QUINAZOLINE DERIVATIVES | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2010-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100009958-A1 | QUINAZOLINE DERIVATIVES | NQO2, ABL1, RECQL | EGFR 1042/4885GAK 493/4885RIPK2 1407/4885 |
| US-20130217661-A1 | QUINAZOLINE DERIVATIVES | NQO2, ABL1, RECQL | EGFR 1042/4885GAK 493/4885RIPK2 1407/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.