Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | CLK2 | P49760 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.37 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.37 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.37 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355101 | 0.80 | HPGD (0.33) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL1355102 | 0.80 | HPGD (0.33) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL22439400 | 0.74 | NQO2 (0.42) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL3188752 | 0.74 | ELANE (0.44) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL15071013 | 0.73 | RXFP1 (0.40) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL25104279 | 0.73 | EGFR (0.33) | ALDH1A1 | |
| SCHEMBL22439098 | 0.71 | NQO2 (0.49) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL21979027 | 0.71 | PLK4 (0.35) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL31682519 | 0.71 | PLK4 (0.38) | PLK4AURKADAPK3CDK1PIM1 | |
| SCHEMBL1352904 | 0.70 | PLK4 (0.34) | PLK4AURKADAPK3CDK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11447471-B2 | α,β-unsaturated amide compound | KYOWA KIRIN CO., LTD. (JP) | 2022-09-20 | — | — | US | disclosed |
| US-20210155612-A1 | Alpha,Beta-UNSATURATED AMIDE COMPOUND | KYOWA KIRIN CO., LTD. (JP) | 2021-05-27 | — | — | US | disclosed |
| EP-3712129-A1 | ALPHA, BETA-UNSATURATED AMIDE COMPOUND | Kyowa Kirin Co., Ltd. (JP) | 2020-09-23 | — | — | EP | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-9216973-B2 | Insecticidal compounds | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-22 | — | — | US | disclosed |
| US-8859592-B2 | Insecticidal compounds | SYNGENTA CORP PROTECTION LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859592-B2 | Insecticidal compounds | SYNGENTA CORP PROTECTION LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-8859592-B2 | Insecticidal compounds | SYNGENTA CORP PROTECTION LLC (US) | 2014-10-14 | — | — | US | disclosed |
| US-20130245072-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CORP PROTECTION LLC (US) | 2013-09-19 | — | — | US | disclosed |
| US-20110288089-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA CROP PROTECTION LLC (US) | 2011-11-03 | — | — | US | disclosed |
| EP-2379541-A2 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2011-10-26 | — | — | EP | disclosed |
| EP-2331536-A1 | INSECTICIDAL COMPOUNDS | Syngenta Participations AG (CH) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010084067-A2 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010084067-A2 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-07-29 | — | — | WO | disclosed |
| WO-2010020522-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
| WO-2010020522-A1 | INSECTICIDAL COMPOUNDS | SYNGENTA PARTICIPATIONS AG (CH) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155612-A1 | Alpha,Beta-UNSATURATED AMIDE COMPOUND | NR1H2, NR1H3, RXRA | PLK4 3151/4885AURKA 2190/4885DAPK3 3039/4885 |
| US-20110288089-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CHRM2 | PLK4 4471/4885AURKA 1349/4885DAPK3 3965/4885 |
| US-11447471-B2 | α,β-unsaturated amide compound | NR1H2, RXRA, RXRB | PLK4 3311/4885AURKA 1926/4885DAPK3 2882/4885 |
| US-20130245072-A1 | INSECTICIDAL COMPOUNDS | ACHE, CHRM1, CHRM2 | PLK4 4471/4885AURKA 1349/4885DAPK3 3965/4885 |
| US-20110269804-A1 | INSECTICIDAL COMPOUNDS | CHRM1, CHRM2, C1R | PLK4 4823/4885AURKA 1951/4885DAPK3 4555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.