Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 2/20 | 0.47 |
| ▸ | CASP7 | P55210 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13917924 | 0.96 | TP53 (0.51) | TP53MAPTKDM4EGLAGAA | |
| SCHEMBL13554386 | 0.86 | NPC1 (0.44) | TP53NPC1RAB9ANCOA1NCOA3 | |
| SCHEMBL28364398 | 0.82 | NPC1 (0.41) | TP53MAPTKDM4ENPC1RAB9A | |
| SCHEMBL28368521 | 0.82 | NPC1 (0.41) | TP53MAPTNPC1RAB9ANCOA1 | |
| SCHEMBL16871074 | 0.82 | NPC1 (0.41) | TP53MAPTNPC1RAB9ANCOA1 | |
| SCHEMBL28364396 | 0.82 | NPC1 (0.41) | TP53MAPTKDM4ENPC1RAB9A | |
| SCHEMBL13554387 | 0.82 | CTDSP1 (0.43) | TP53MAPTGAANPC1RAB9A | |
| SCHEMBL13932254 | 0.79 | NPC1 (0.46) | TP53NPC1RAB9ANCOA1NCOA3 | |
| SCHEMBL13917922 | 0.77 | CTDSP1 (0.45) | TP53MAPTGAANPC1RAB9A | |
| SCHEMBL13917915 | 0.76 | NPC1 (0.42) | TP53NPC1RAB9ANCOA1NCOA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160025713-A1 | SITE-SPECIFIC LABELING OF AFFINITY TAGS IN FUSION PROTEINS | LIFE TECHNOLOGIES CORP (US) | 2016-01-28 | — | — | US | disclosed |
| US-9164099-B2 | Site-specific labeling of affinity tags in fusion proteins | Life Technologies Corporation (US) | 2015-10-20 | — | — | US | disclosed |
| US-20140038856-A1 | Site-specific labeling of affinity tags in fusion proteins | Life Technologies Corporation (US) | 2014-02-06 | — | — | US | disclosed |
| US-20120270757-A1 | SITE-SPECIFIC LABELING OF AFFINITY TAGS IN FUSION PROTEINS | Life Technologies Corporation (US) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160025713-A1 | SITE-SPECIFIC LABELING OF AFFINITY TAGS IN FUSION PROTEINS | APBA1, F13A1, F13B | TP53 821/4885MAPT 2359/4885KDM4E 4156/4885 |
| US-20120270757-A1 | SITE-SPECIFIC LABELING OF AFFINITY TAGS IN FUSION PROTEINS | APBA1, NAPA, F13B | TP53 931/4885MAPT 2185/4885KDM4E 4084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.