Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.50 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | F2R | P25116 | 5/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13388238 | 0.81 | GRM5 (0.69) | GRM5 | |
| SCHEMBL13555902 | 0.80 | MLNR (0.48) | MCHR1HTR2CKCNH2MLNRF2R | |
| SCHEMBL13555964 | 0.80 | GRM5 (0.67) | MLNRGRM5MAP4K4GRIN2B | |
| SCHEMBL13555876 | 0.78 | MAP4K4 (0.56) | NPC1RAB9AGRM5MAP4K4 | |
| SCHEMBL13555877 | 0.76 | MLNR (0.45) | MCHR1HTR2CKCNH2MLNRF2R | |
| SCHEMBL18924349 | 0.75 | ABL1 (0.47) | MCHR1HTR2CKCNH2NPC1RAB9A | |
| SCHEMBL486067 | 0.75 | KMO (0.59) | MAP4K4 | |
| SCHEMBL18924536 | 0.75 | S1PR1 (0.43) | MCHR1HTR2CKCNH2NPC1RAB9A | |
| SCHEMBL18924458 | 0.74 | DYRK1A (0.52) | MCHR1HTR2CKCNH2NPC1RAB9A | |
| SCHEMBL20460410 | 0.73 | ALDH1A1 (0.47) | MCHR1HTR2CKCNH2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2012-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120270852-A1 | PHENYL OR PYRIDINYL-ETHYNYL DERIVATIVES | GRM5, GRM1, GRM3 | MCHR1 270/4885HTR2C 62/4885KCNH2 330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.