Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK4 | Q9P2K8 | 4/20 | 0.61 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.56 |
| ▸ | FLT3 | P36888 | 7/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | FLT1 | P17948 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355771 | 0.90 | EIF2AK4 (0.64) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1355858 | 0.88 | EIF2AK4 (0.61) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1356186 | 0.86 | EIF2AK4 (0.67) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1356682 | 0.85 | EIF2AK4 (0.61) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1356020 | 0.84 | TBK1 (0.74) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1353635 | 0.83 | EIF2AK4 (0.66) | EIF2AK4TBK1FLT3FGFR1PTK2 | |
| SCHEMBL1355821 | 0.82 | EIF2AK4 (0.62) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1356007 | 0.81 | EIF2AK4 (0.67) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1356019 | 0.81 | EIF2AK4 (0.61) | EIF2AK4TBK1FLT3AURKADAPK3 | |
| SCHEMBL1353796 | 0.81 | EIF2AK4 (0.53) | EIF2AK4TBK1FLT3AURKADAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | EIF2AK4 791/4885TBK1 1295/4885FLT3 766/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | EIF2AK4 791/4885TBK1 1295/4885FLT3 766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.