Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 5/20 | 0.44 |
| ▸ | NPY1R | P25929 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13105496 | 0.84 | GRIA1 (0.46) | NPY5RNPY1RHDAC1HDAC2HDAC8 | |
| SCHEMBL10113597 | 0.82 | HDAC1 (0.64) | HDAC1HDAC2HDAC6CYSLTR2CYSLTR1 | |
| SCHEMBL28608296 | 0.80 | GPBAR1 (0.49) | HDAC1HDAC2HDAC8HDAC6SLC2A1 | |
| SCHEMBL13564784 | 0.79 | NPY5R (0.67) | NPY5RNPY1RHDAC1HDAC2HDAC8 | |
| SCHEMBL10614795 | 0.78 | HDAC1 (0.48) | HDAC1HDAC2HDAC8HDAC6CHRM2 | |
| SCHEMBL11935004 | 0.77 | MC4R (0.48) | HDAC1HDAC2HDAC8HDAC6CHRM2 | |
| SCHEMBL3269912 | 0.77 | GPBAR1 (0.48) | HDAC1HDAC2HDAC8HDAC6CYP1A2 | |
| SCHEMBL30022211 | 0.77 | GPBAR1 (0.48) | HDAC1HDAC2HDAC8HDAC6CYP1A2 | |
| SCHEMBL13565493 | 0.76 | CA2 (0.49) | NPY5RNPY1RSLC2A1CHRM2CYP1A2 | |
| SCHEMBL30388584 | 0.76 | KDM1A (0.50) | HDAC1HDAC2HDAC8HDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |