Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 8/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565977 | 0.92 | GRIA1 (0.37) | GRIA1NPY5RTRPV1BRD4KDM4E | |
| SCHEMBL17090277 | 0.92 | GRIA1 (0.37) | GRIA1NPY5RTRPV1BRD4KDM4E | |
| SCHEMBL13565167 | 0.90 | GRIA1 (0.36) | GRIA1NPY5RTRPV1BRD4KDM4E | |
| SCHEMBL17090279 | 0.90 | GRIA1 (0.36) | GRIA1NPY5RTRPV1BRD4KDM4E | |
| SCHEMBL17090541 | 0.87 | NPY5R (0.42) | GRIA1NPY5RTRPV1BRD4HTR1A | |
| SCHEMBL13564951 | 0.87 | NPY5R (0.42) | GRIA1NPY5RTRPV1BRD4HTR1A | |
| SCHEMBL17090058 | 0.87 | GRIA1 (0.40) | GRIA1NPY5RBRD4KDM4ELMNA | |
| SCHEMBL13564973 | 0.87 | GRIA1 (0.40) | GRIA1NPY5RBRD4KDM4ELMNA | |
| SCHEMBL13565166 | 0.87 | GRIA1 (0.40) | GRIA1NPY5RBRD4KDM4ELMNA | |
| SCHEMBL10115300 | 0.85 | KMT2A (0.38) | TRPV1KDM4ELMNAHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |