Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 7/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.34 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565087 | 0.88 | GRIA2 (0.37) | GRIA2NPY5RCYP3A4CYP2C8 | |
| SCHEMBL13565403 | 0.85 | GPR119 (0.44) | GPR119NPY5RBAZ2BMKNK1MAPK14 | |
| SCHEMBL17090302 | 0.85 | GPR119 (0.44) | GPR119NPY5RBAZ2BMKNK1MAPK14 | |
| SCHEMBL11935136 | 0.83 | NPY5R (0.41) | GRIA2NPY5RCYP3A4CYP2C8 | |
| SCHEMBL11936151 | 0.83 | NPY5R (0.41) | GRIA2NPY5RCYP3A4CYP2C8 | |
| SCHEMBL13565430 | 0.82 | PARG (0.47) | GRIA2NPY5RCYP3A4 | |
| SCHEMBL17090115 | 0.80 | CNR2 (0.48) | GRIA2 | |
| SCHEMBL17090535 | 0.80 | GRIA2 (0.44) | GRIA2 | |
| SCHEMBL13565168 | 0.80 | GRIA2 (0.44) | GRIA2 | |
| SCHEMBL11935401 | 0.80 | CNR2 (0.39) | GRIA2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |