Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565675 | 0.84 | HDAC8 (0.51) | HDAC8TP53LMNAALDH1A1MAPK1 | |
| SCHEMBL13565500 | 0.83 | ALDH1A1 (0.53) | TP53LMNAALDH1A1MAPK1MEN1 | |
| SCHEMBL13565237 | 0.83 | MRGPRX4 (0.44) | TP53LMNAALDH1A1MEN1KMT2A | |
| SCHEMBL13565238 | 0.82 | CA1 (0.54) | LMNAALDH1A1MEN1KMT2AHTT | |
| SCHEMBL11936088 | 0.81 | TUBB4A (0.50) | LMNAALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL13565241 | 0.80 | MEN1 (0.53) | LMNAMEN1KMT2AMAPTNPC1 | |
| SCHEMBL11936067 | 0.79 | CA1 (0.45) | ALDH1A1MEN1KMT2AMAPTCA1 | |
| SCHEMBL10116493 | 0.78 | HDAC1 (0.57) | HDAC8TP53LMNAALDH1A1MAPK1 | |
| SCHEMBL13565502 | 0.77 | CTPS1 (0.45) | LMNAALDH1A1MAPTNPC1 | |
| SCHEMBL11935889 | 0.76 | HDAC8 (0.57) | HDAC8LMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |