Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 3/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 7/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13565287 | 0.85 | CNR2 (0.35) | CNR2ALDH1A1PKMUSP2 | |
| SCHEMBL10115508 | 0.85 | ALDH1A1 (0.42) | HTR1AALDH1A1PKMUSP2 | |
| SCHEMBL11935821 | 0.82 | GRIA1 (0.45) | GRIA1NPY5RKCNH2HRH1ALDH1A1 | |
| SCHEMBL13565799 | 0.81 | GRIA1 (0.44) | GRIA1NPY5RKCNH2HRH1ALDH1A1 | |
| SCHEMBL11935717 | 0.80 | GAA (0.37) | — | |
| SCHEMBL13565895 | 0.80 | GRIA1 (0.45) | GRIA1NPY5RKCNH2CNR2 | |
| SCHEMBL13565487 | 0.79 | GRIA1 (0.42) | GRIA1NPY5RKDM1AGRIA4 | |
| SCHEMBL13565144 | 0.79 | CTSL (0.44) | GRIA1NPY5RKCNH2HRH1 | |
| SCHEMBL11936141 | 0.78 | HRH3 (0.41) | ALDH1A1 | |
| SCHEMBL11935850 | 0.78 | GRIA1 (0.41) | GRIA1NPY5RKDM1AHTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |