Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PTPRC | P08575 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 5/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13566021 | 0.90 | NPY5R (0.36) | CYP2D6SLC6A2SLC6A4SLC6A3NPY5R | |
| SCHEMBL13565839 | 0.83 | NPY5R (0.48) | TPSAB1CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10113639 | 0.83 | MEN1 (0.47) | MEN1KMT2AHTR2CHTR2AKDM4E | |
| SCHEMBL13565198 | 0.81 | NPY5R (0.37) | CYP2D6NPY5RCNR2ALDH1A1 | |
| SCHEMBL18415591 | 0.79 | ABL1 (0.52) | CYP2D6SLC6A2SLC6A4SLC6A3CNR2 | |
| SCHEMBL13565257 | 0.79 | ALDH1A1 (0.46) | NPY5RCNR2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13565919 | 0.78 | ABL1 (0.46) | CNR2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13564775 | 0.77 | PKM (0.36) | NPY5RCNR2NPC1ALDH1A1TP53 | |
| SCHEMBL13565161 | 0.77 | CNR2 (0.40) | CNR2MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL13565181 | 0.76 | ALDH1A1 (0.42) | NPY5RMEN1KMT2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |
| US-8299265-B2 | Amine derivatives having NPY Y5 receptor antagonistic activity and the uses thereof | SHIONOGI & CO., LTD. (JP) | 2012-10-30 | — | — | US | disclosed |